{"id":10987,"date":"2019-01-03T14:22:10","date_gmt":"2019-01-03T19:22:10","guid":{"rendered":"https:\/\/research.ncsu.edu\/otcnv\/?p=10987"},"modified":"2023-11-20T19:42:57","modified_gmt":"2023-11-21T00:42:57","slug":"locus-biosciences-enters-a-collaboration-and-license-agreement-with-johnson-johnson-innovation-to-develop-crispr-cas3-bacteriophage-therapeutics","status":"publish","type":"post","link":"https:\/\/research.ncsu.edu\/commercialization\/2019\/01\/03\/locus-biosciences-enters-a-collaboration-and-license-agreement-with-johnson-johnson-innovation-to-develop-crispr-cas3-bacteriophage-therapeutics\/","title":{"rendered":"Locus Biosciences Enters a Collaboration and License Agreement with Johnson &amp; Johnson Innovation to develop CRISPR-Cas3 Bacteriophage Therapeutics"},"content":{"rendered":"\n\n\n\n\n<p class=\"wp-block-paragraph\">Locus Biosciences Inc., a biotechnology company developing precision antibacterial therapies, announced today that it has entered into an exclusive collaboration and license agreement with Janssen Pharmaceuticals, Inc. (Janssen), one of the Janssen Pharmaceutical Companies of Johnson &amp; Johnson, to develop, manufacture and commercialize CRISPR-Cas3-enhanced bacteriophage (&#8220;crPhage\u2122&#8221;) products targeting two key bacterial pathogens for the potential treatment of infections of the respiratory tract and other organ systems. &nbsp;Johnson &amp; Johnson Innovation LLC facilitated the transaction.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Under the terms of the agreement, Locus will receive&nbsp;<span class=\"xn-money\">$20 million<\/span>&nbsp;in initial payments, and is eligible to receive up to a total of&nbsp;<span class=\"xn-money\">$798 million<\/span>&nbsp;in potential future development and commercial milestone payments, and royalties on any product sales.<\/p>\n\n\n<div class=\"wp-block-ncst-buttons\"><div class=\"wp-block-ncst-button\"><a href=\"https:\/\/www.prnewswire.com\/news-releases\/locus-biosciences-enters-a-collaboration-and-license-agreement-with-johnson--johnson-innovation-to-develop-crispr-cas3-bacteriophage-therapeutics-300771975.html\" class=\"btn ncst-block__button-link\" data-ncst-lightbox=\"false\" data-ua-cat=\"Button Block\" data-ua-action=\"Button Click\" data-ua-label=\"https:\/\/www.prnewswire.com\/news-releases\/locus-biosciences-enters-a-collaboration-and-license-agreement-with-johnson--johnson-innovation-to-develop-crispr-cas3-bacteriophage-therapeutics-300771975.html\"><span class=\"text\">Read More<\/span><span class=\"arrow-indicator\"><svg \n\tclass=\"wolficon wolficon-arrow-right-bold\"\n\trole=\"img\"\n\taria-hidden=\"1\">\n\t\t<use xlink:href=\"#wolficon-arrow-right-bold\"><\/use>\n<\/svg>\n<\/span><\/a><\/div>\n\n<\/div>\n\n","protected":false,"raw":"<!-- wp:ncst\/dynamic-header {\"block\":\"ncst\/default-post-header\"} -->\n<!-- wp:ncst\/default-post-header {\"caption\":\"\",\"showAuthor\":false,\"showReadingTime\":false} \/-->\n<!-- \/wp:ncst\/dynamic-header -->\n\n<!-- wp:paragraph -->\n<p>Locus Biosciences Inc., a biotechnology company developing precision antibacterial therapies, announced today that it has entered into an exclusive collaboration and license agreement with Janssen Pharmaceuticals, Inc. (Janssen), one of the Janssen Pharmaceutical Companies of Johnson &amp; Johnson, to develop, manufacture and commercialize CRISPR-Cas3-enhanced bacteriophage (\"crPhage\u2122\") products targeting two key bacterial pathogens for the potential treatment of infections of the respiratory tract and other organ systems. &nbsp;Johnson &amp; Johnson Innovation LLC facilitated the transaction.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Under the terms of the agreement, Locus will receive&nbsp;<span class=\"xn-money\">$20 million<\/span>&nbsp;in initial payments, and is eligible to receive up to a total of&nbsp;<span class=\"xn-money\">$798 million<\/span>&nbsp;in potential future development and commercial milestone payments, and royalties on any product sales.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:ncst\/buttons -->\n<div class=\"wp-block-ncst-buttons\"><!-- wp:ncst\/button -->\n<div class=\"wp-block-ncst-button\"><a href=\"https:\/\/www.prnewswire.com\/news-releases\/locus-biosciences-enters-a-collaboration-and-license-agreement-with-johnson--johnson-innovation-to-develop-crispr-cas3-bacteriophage-therapeutics-300771975.html\" class=\"btn ncst-block__button-link\" data-ncst-lightbox=\"false\" data-ua-cat=\"Button Block\" data-ua-action=\"Button Click\" data-ua-label=\"https:\/\/www.prnewswire.com\/news-releases\/locus-biosciences-enters-a-collaboration-and-license-agreement-with-johnson--johnson-innovation-to-develop-crispr-cas3-bacteriophage-therapeutics-300771975.html\"><span class=\"text\">Read More<\/span><span class=\"arrow-indicator\"><!-- wp:ncst\/wolficon {\"slug\":\"arrow-right-bold\"} -->\n<svg class=\"wp-block-ncst-wolficon wolficon\" role=\"img\" aria-hidden=\"true\"><use xlink:href=\"#wolficon-arrow-right-bold\"\/><\/svg>\n<!-- \/wp:ncst\/wolficon --><\/span><\/a><\/div>\n<!-- \/wp:ncst\/button --><\/div>\n<!-- \/wp:ncst\/buttons -->"},"excerpt":{"rendered":"<p>Locus Biosciences Inc., a biotechnology company developing precision antibacterial therapies, announced today that it has entered into an exclusive collaboration and license agreement with Janssen Pharmaceuticals, Inc. (Janssen), one of the Janssen Pharmaceutical Companies of Johnson &amp; Johnson, to develop, manufacture and commercialize CRISPR-Cas3-enhanced bacteriophage (&#8220;crPhage\u2122&#8221;) products targeting two key bacterial pathogens for the potential treatment of infections of the respiratory tract and other organ systems. \u00a0Johnson &amp; Johnson Innovation LLC facilitated the transaction.<\/p>\n","protected":false},"author":239,"featured_media":15171,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"source":"","ncst_custom_author":"","ncst_show_custom_author":false,"ncst_dynamicHeaderBlockName":"ncst\/default-post-header","ncst_dynamicHeaderData":"{\"showAuthor\":false,\"showDate\":true,\"showFeaturedVideo\":false,\"caption\":\"\",\"showReadingTime\":false}","ncst_content_audit_freq":"","ncst_content_audit_date":"","ncst_content_audit_display":false,"ncst_backToTopFlag":"","footnotes":""},"categories":[2,3],"tags":[],"_ncst_magazine_issue":[],"class_list":["post-10987","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-startup-news"],"displayCategory":null,"acf":{"ncst_posts_meta_modified_date":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Locus Biosciences Enters a Collaboration and License Agreement with Johnson &amp; Johnson Innovation to develop CRISPR-Cas3 Bacteriophage Therapeutics - Office of Research Commercialization<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/research.ncsu.edu\/commercialization\/2019\/01\/03\/locus-biosciences-enters-a-collaboration-and-license-agreement-with-johnson-johnson-innovation-to-develop-crispr-cas3-bacteriophage-therapeutics\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Locus Biosciences Enters a Collaboration and License Agreement with Johnson &amp; Johnson Innovation to develop CRISPR-Cas3 Bacteriophage Therapeutics - Office of Research Commercialization\" \/>\n<meta property=\"og:description\" content=\"Locus Biosciences Inc., a biotechnology company developing precision antibacterial therapies, announced today that it has entered into an exclusive collaboration and license agreement with Janssen Pharmaceuticals, Inc. (Janssen), one of the Janssen Pharmaceutical Companies of Johnson &amp; Johnson, to develop, manufacture and commercialize CRISPR-Cas3-enhanced bacteriophage (&quot;crPhage\u2122&quot;) products targeting two key bacterial pathogens for the potential treatment of infections of the respiratory tract and other organ systems. \u00a0Johnson &amp; Johnson Innovation LLC facilitated the transaction.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/research.ncsu.edu\/commercialization\/2019\/01\/03\/locus-biosciences-enters-a-collaboration-and-license-agreement-with-johnson-johnson-innovation-to-develop-crispr-cas3-bacteriophage-therapeutics\/\" \/>\n<meta property=\"og:site_name\" content=\"Office of Research Commercialization\" \/>\n<meta property=\"article:published_time\" content=\"2019-01-03T19:22:10+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-11-21T00:42:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/research.ncsu.edu\/commercialization\/files\/2019\/02\/ORC-news-photo-.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1601\" \/>\n\t<meta property=\"og:image:height\" content=\"900\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Sasha Campbell\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sasha Campbell\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/commercialization\\\/2019\\\/01\\\/03\\\/locus-biosciences-enters-a-collaboration-and-license-agreement-with-johnson-johnson-innovation-to-develop-crispr-cas3-bacteriophage-therapeutics\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/commercialization\\\/2019\\\/01\\\/03\\\/locus-biosciences-enters-a-collaboration-and-license-agreement-with-johnson-johnson-innovation-to-develop-crispr-cas3-bacteriophage-therapeutics\\\/\"},\"author\":{\"name\":\"Sasha Campbell\",\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/commercialization\\\/#\\\/schema\\\/person\\\/2df2b886ab8c62292fb07ec4b03d51e8\"},\"headline\":\"Locus Biosciences Enters a Collaboration and License Agreement with Johnson &amp; 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