{"id":15804,"date":"2025-04-16T09:00:00","date_gmt":"2025-04-16T13:00:00","guid":{"rendered":"https:\/\/research.ncsu.edu\/commercialization\/?p=15804"},"modified":"2025-04-15T12:30:45","modified_gmt":"2025-04-15T16:30:45","slug":"nc-state-science-to-supplement-codonrx-pioneers-a-new-era-in-gut-health","status":"publish","type":"post","link":"https:\/\/research.ncsu.edu\/commercialization\/2025\/04\/16\/nc-state-science-to-supplement-codonrx-pioneers-a-new-era-in-gut-health\/","title":{"rendered":"NC State Science to Supplement:\u00a0CodonRX Pioneers a New Era in Gut Health"},"content":{"rendered":"\n\n\n\n\n

RALEIGH, N.C.<\/strong> \u2014 Innovation at NC State University is transforming lives, one scientific breakthrough at a time. The latest success story, CodonRX, a probiotic supplement designed to reduce gastrointestinal inflammation, is already making an impact on digestive health worldwide.<\/p>\n\n\n\n

Developed from decades of research at NC State, CodonRX represents a rare achievement: university-patented science evolving into a commercial product that directly improves quality of life.<\/p>\n\n\n

\n \u201cOur labs at NC State spent years researching and developing the anti-inflammatory properties of CodonRX,\u201d said Dr. Rodolphe Barrangou, a lead researcher on the project. \u201cI\u2019m thrilled to see CodonRX reach the market and hopeful that it will make a meaningful difference in people’s health.\u201d\n <\/blockquote>\n\n\n\n

From Discovery to Breakthrough<\/strong><\/h4>\n\n\n\n

The foundation for CodonRX dates back more than 40 years to NC State\u2019s Food Microbiology Lab, where scientists first identified Lactobacillus acidophilus<\/em> NCFM, a probiotic strain with promising health benefits. Barrangou and his team later advanced this research by genetically modifying the strain, removing a specific gene to reduce inflammation in the gut. The result was a first-of-its-kind probiotic designed for targeted health benefits.<\/p>\n\n\n

\n \u201cWe always have some level of inflammation\u2014it\u2019s part of our body\u2019s natural balance. But sometimes, it gets out of control,\u201d Barrangou said. \u201cBy engineering probiotics, we can promote a healthier gut environment.\u201d\n <\/blockquote>\n\n\n\n

Science Meets Industry<\/strong><\/h4>\n\n\n\n

This pioneering research led to the launch of CodonRX through NC State\u2019s Office of Research Commercialization (ORC).  ORC quickly identified the value of this project and acted to support commercialization in several ways, including filing for patent protection, assisting with startup logistics, and facilitating execution of a license agreement to give CodonRX rights to this intellectual property. The CodonRX supplement was brought to market by Provaxus, a biotechnology company founded by Yale alumnus and Barrangou collaborator Kevin White.<\/p>\n\n\n\n

White, a seasoned entrepreneur with prior academic and leadership roles at Stanford, Yale and the University of Chicago, has a track record of turning scientific discoveries into commercial success. His previous ventures include Tempus AI, which debuted on Nasdaq in 2024 with a $6.6 billion valuation. With CodonRX, he is once again bridging the gap between laboratory innovation and consumer impact.<\/p>\n\n\n

\n \u201cWe believe this probiotic has the potential to help a broad spectrum of people,\u201d White said. \u201cIt\u2019s exciting to be part of helping to translate NC State\u2019s research into a product that is already changing lives.\u201d\n <\/blockquote>\n\n\n\n

Real-World Results<\/strong><\/h4>\n\n\n\n

For many, probiotic supplements are just another health product on the shelf. But for users of CodonRX, the results speak for themselves.<\/p>\n\n\n\n

Since CodonRX became publicly available last year, it has helped more than 1,000 patients find relief from irritable bowel syndrome and other digestive tract issues. By partnering with gastroenterologists and surgeons, the CodonRX team has worked to improve patient outcomes and quality of life. Both providers and patients have reported that CodonRX offers faster relief from constipation, diarrhea, bloating, abdominal pain and gas compared to generic probiotics.<\/p>\n\n\n

\n \u201cCodonRX worked for me,\u201d said Cindy, a customer from Wisconsin. \u201cI took it for a month, and so far, it has kept me from feeling bloated and, most importantly, has kept me regular.\u201d\n <\/blockquote>\n\n\n\n

Another user shared even quicker results: \u201cSaw improvements in one to two weeks, will continue to take and monitor.\u201d<\/p>\n\n\n\n

A Model for Future Innovation<\/strong><\/h4>\n\n\n\n

Looking ahead, CodonRX is expanding its impact beyond the supplement itself. Later this year, the company will introduce a free companion mobile app designed to support patients using CodonRX. The app will allow users to track symptoms, monitor bowel health and receive personalized insights, offering valuable data to both patients and their doctors.<\/p>\n\n\n\n

With this expansion, CodonRX is more than just a breakthrough in gut health\u2014it\u2019s a testament to NC State\u2019s commitment to turning research into real-world solutions through advancements across biotechnology, agriculture, engineering and health sciences.<\/p>\n\n\n\n

Barrangou and his team are already exploring new probiotic applications for digestion, metabolism and brain function, aiming to push the boundaries of microbiome science.<\/p>\n\n\n\n

For NC State alumni, researchers and entrepreneurs, CodonRX serves as a powerful example of what\u2019s possible when academia and industry collaborate.<\/p>\n\n\n

\n \u201cIt\u2019s not typical in academia to go from step one in genetic engineering to actually seeing a product on the market that people can buy and use,\u201d said Dr. Sarah O\u2019Flaherty, a senior research scholar in Barrangou\u2019s lab. \u201cIt\u2019s an honor to see it go from A to Z.\u201d\n <\/blockquote>\n\n\n\n

And for the millions of people struggling with gut health, it\u2019s just the beginning of a new era in probiotic science.<\/p>\n\n\n\n

For more information on the lab of Dr. Barrangou, visit <\/strong>go.ncsu.edu\/barrangou_lab<\/strong><\/a>.<\/strong><\/p>\n\n\n\n

For more information on CodonRX, visit<\/strong> <\/strong>codonrx.com<\/strong><\/a>.<\/strong><\/p>\n","protected":false,"raw":"\n\n\n\n\n

RALEIGH, N.C.<\/strong> \u2014 Innovation at NC State University is transforming lives, one scientific breakthrough at a time. The latest success story, CodonRX, a probiotic supplement designed to reduce gastrointestinal inflammation, is already making an impact on digestive health worldwide.<\/p>\n\n\n\n

Developed from decades of research at NC State, CodonRX represents a rare achievement: university-patented science evolving into a commercial product that directly improves quality of life.<\/p>\n\n\n\n\n\n

From Discovery to Breakthrough<\/strong><\/h4>\n\n\n\n

The foundation for CodonRX dates back more than 40 years to NC State\u2019s Food Microbiology Lab, where scientists first identified Lactobacillus acidophilus<\/em> NCFM, a probiotic strain with promising health benefits. Barrangou and his team later advanced this research by genetically modifying the strain, removing a specific gene to reduce inflammation in the gut. The result was a first-of-its-kind probiotic designed for targeted health benefits.<\/p>\n\n\n\n\n\n

Science Meets Industry<\/strong><\/h4>\n\n\n\n

This pioneering research led to the launch of CodonRX through NC State\u2019s Office of Research Commercialization (ORC).  ORC quickly identified the value of this project and acted to support commercialization in several ways, including filing for patent protection, assisting with startup logistics, and facilitating execution of a license agreement to give CodonRX rights to this intellectual property. The CodonRX supplement was brought to market by Provaxus, a biotechnology company founded by Yale alumnus and Barrangou collaborator Kevin White.<\/p>\n\n\n\n

White, a seasoned entrepreneur with prior academic and leadership roles at Stanford, Yale and the University of Chicago, has a track record of turning scientific discoveries into commercial success. His previous ventures include Tempus AI, which debuted on Nasdaq in 2024 with a $6.6 billion valuation. With CodonRX, he is once again bridging the gap between laboratory innovation and consumer impact.<\/p>\n\n\n\n\n\n

Real-World Results<\/strong><\/h4>\n\n\n\n

For many, probiotic supplements are just another health product on the shelf. But for users of CodonRX, the results speak for themselves.<\/p>\n\n\n\n

Since CodonRX became publicly available last year, it has helped more than 1,000 patients find relief from irritable bowel syndrome and other digestive tract issues. By partnering with gastroenterologists and surgeons, the CodonRX team has worked to improve patient outcomes and quality of life. Both providers and patients have reported that CodonRX offers faster relief from constipation, diarrhea, bloating, abdominal pain and gas compared to generic probiotics.<\/p>\n\n\n\n\n\n

Another user shared even quicker results: \u201cSaw improvements in one to two weeks, will continue to take and monitor.\u201d<\/p>\n\n\n\n

A Model for Future Innovation<\/strong><\/h4>\n\n\n\n

Looking ahead, CodonRX is expanding its impact beyond the supplement itself. Later this year, the company will introduce a free companion mobile app designed to support patients using CodonRX. The app will allow users to track symptoms, monitor bowel health and receive personalized insights, offering valuable data to both patients and their doctors.<\/p>\n\n\n\n

With this expansion, CodonRX is more than just a breakthrough in gut health\u2014it\u2019s a testament to NC State\u2019s commitment to turning research into real-world solutions through advancements across biotechnology, agriculture, engineering and health sciences.<\/p>\n\n\n\n

Barrangou and his team are already exploring new probiotic applications for digestion, metabolism and brain function, aiming to push the boundaries of microbiome science.<\/p>\n\n\n\n

For NC State alumni, researchers and entrepreneurs, CodonRX serves as a powerful example of what\u2019s possible when academia and industry collaborate.<\/p>\n\n\n\n\n\n

And for the millions of people struggling with gut health, it\u2019s just the beginning of a new era in probiotic science.<\/p>\n\n\n\n

For more information on the lab of Dr. Barrangou, visit <\/strong>go.ncsu.edu\/barrangou_lab<\/strong><\/a>.<\/strong><\/p>\n\n\n\n

For more information on CodonRX, visit<\/strong> <\/strong>codonrx.com<\/strong><\/a>.<\/strong><\/p>\n"},"excerpt":{"rendered":"

Innovation at NC State University is transforming lives, one scientific breakthrough at a time. The latest success story, CodonRX, a probiotic supplement designed to reduce gastrointestinal inflammation, is already making an impact on digestive health worldwide.<\/p>\n","protected":false},"author":239,"featured_media":15806,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"source":"","ncst_custom_author":"","ncst_show_custom_author":false,"ncst_dynamicHeaderBlockName":"ncst\/default-post-header","ncst_dynamicHeaderData":"{\"displayCategoryID\":2,\"showAuthor\":false,\"showDate\":false,\"showFeaturedVideo\":false,\"showReadingTime\":false}","ncst_content_audit_freq":"","ncst_content_audit_date":"","ncst_content_audit_display":false,"ncst_backToTopFlag":"","footnotes":""},"categories":[2],"tags":[35,280,54,282,75,283,278,99,140,279],"_ncst_magazine_issue":[],"class_list":["post-15804","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-biotech","tag-codonrx","tag-commercialization","tag-digestive-health","tag-entrepreneurship","tag-food-microbiology-lab","tag-gut-health","tag-innovation","tag-nc-state","tag-probiotics"],"displayCategory":{"term_id":2,"name":"News","slug":"news","term_group":0,"term_taxonomy_id":2,"taxonomy":"category","description":"","parent":0,"count":151,"filter":"raw"},"acf":{"ncst_posts_meta_modified_date":""},"yoast_head":"\nNC State Science to Supplement:\u00a0CodonRX Pioneers a New Era in Gut Health - Office of Research Commercialization<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/research.ncsu.edu\/commercialization\/2025\/04\/16\/nc-state-science-to-supplement-codonrx-pioneers-a-new-era-in-gut-health\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NC State Science to Supplement:\u00a0CodonRX Pioneers a New Era in Gut Health - Office of Research Commercialization\" \/>\n<meta property=\"og:description\" content=\"Innovation at NC State University is transforming lives, one scientific breakthrough at a time. 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