Bio

Dr. Fred Gould is Co-Director of the Genetic Engineering and Society Center of North Carolina State University and Director of the NSF-sponsored, interdisciplinary, graduate training program on Agricultural Biotechnology. He conducts research on the application of evolutionary biology and population genetics to enable sustainable use of insect resistant crops and genetically engineered agricultural pests. He also does research on strategies for development and use of engineered mosquitoes to decrease human disease. In this regard, Dr. Gould and his colleagues have studied the field ecology of the mosquito, Aedes aegypti, that vectors dengue virus. They have also developed a range of mathematical models to assess current gene drive systems and to conceptualize novel gene drive mechanisms.

In 2011, Dr. Gould was elected to the U.S. National Academy of Sciences (NAS). He has served on several National Academy of Sciences Engineering and Medicine (NASEM) committees studying the environmental and health effects of the commercialization of genetically engineered crops. Dr. Gould chaired the 2014-2016 NASEM committee on “Genetically Engineered Crops: Experiences and Prospects” and was a reviewer of the NASEM 2016 report on Gene Drives. He serves on the NASEM’s Board on Agriculture and Natural Resources and is a member of the Target Malaria Ethics Committee. Dr. Gould received his BS in Biology from Queens College-CUNY, and a PhD in Ecology and Evolutionary Biology from the State University of New York at Stony Brook. He started work at NC State as a Postdoc in 1977.

Education

Postdoctoral Associate, NC State University; PhD, State University of New York at Stony Brook; BS, Queens College-CUNY

Expertise

Entomology, Pest ecology, Gene drives, Bt Crops

Grants & Projects

• Gould, F. (Co-PI). Genomic Monitoring Approaches for Improving Insect Resistance Risk Assessment and Management in Transgenic Crops. USDA – $499,000. 2019-2022. (PI Megan Fritz (UMD) Co-PI Gould) $91,000 (to NC State)
• Gould, F. (PI).Combining Aedes aegypti genomics & modeling to improve gene drive strategies and our understanding of resistance evolution. NIH – $1,867,000. 2018-2023 (PI Gould Co-PI Alun Lloyd, Amy Morrison)
• Gould, F. (PI). Agricultural Biotechnology in Our Evolving Food, Energy & Water Systems (AgBioFEWS). F. Gould PI, Z. Brown, J. Delborne, J. Kuzma, and H. Sederoff coPI. National Science Foundation, National Research Traineeships Program – $2,997,350. 2018-2023.

Featured In

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Awards

• Founders’ Memorial Award from Entomological Society of America, 2014
• NC State University Borlaug Award for Service to Society and Environment, 2013
• O. Max Gardner Award – UNC faculty member with greatest contribution to human welfare, 2012
• Elected to be a member of the National Academy of Sciences, 2011
• Alexander Quarles Holladay Medal for career achievement at NC State Univ. 2011
• Fellow of the American Association for the Advancement of Science (AAAS), 2011
• George Bugliarello Prize from Sigma Xi for article on genetic manipulation of pests for control of human disease vectors, 2007
• Alexander von Humboldt award for most significant agricultural research over a five-year period, 2004

Highlighted Publications

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Fritz, M. L. A. M. DeYonke, A. Papanicolaou, S. Micinski, J. Westbrook and F. Gould. 2018.
Contemporary evolution of a Lepidopteran species, Heliothis virescens, in response to modern agricultural practices. Molecular Ecology 27:167-181 DOI: 10.1111/mec.14430

Gould, F., Brown, Z. S., and Kuzma, J. 2018. Wicked evolution: can we address the sociobiological dilemma of pesticide resistance? Science 360, 728–732. doi: 10.1126/science.aar3780

Gunning C. E., K. W. Okamoto, H. Astete, G. M. Vasquez, E. Erhardt, C Del Aguila, R. Pinedo, R. Cardenas, C. Pacheco, E. Chalco, H. Rodriguez-Ferruci, T. W. Scott, A. L. Lloyd, F. Gould, A. C. Morrison. 2018. Efficacy of Aedes aegypti control by indoor Ultra Low Volume (ULV) insecticide spraying in Iquitos, Peru. PLoS Negl Trop Dis 12(4): e0006378. https:// doi.org/10.1371/journal.pntd.0006378

Brossard, D., P. Belluck, F. Gould, C. D. Wirz. 2019. Promises and Perils of Gene Drives: Navigating the Communication of Complex, Post-Normal Science. Proc. Nat. Acad. Sci. doi: 10.1073/pnas.1805874115

Sudweeks, J., Hollingsworth, B., Blondel, D. V., Campbell, K. J., Dhole, S., Eisemann, J. D., … Gould, F., Lloyd, A. L. (2019). Locally Fixed Alleles: A method to localize gene drive to island populations. SCIENTIFIC REPORTS, 9. https://doi.org/10.1038/s41598-019-51994-0

Dhole, S., Lloyd, A. L., & Gould, F. (2019). Tethered homing gene drives: A new design for spatially restricted population replacement and suppression. EVOLUTIONARY APPLICATIONS, 12(8), 1688–1702. https://doi.org/10.1111/eva.12827

Cash, S. A., Lorenzen, M. D., & Gould, F. (2019). The distribution and spread of naturally occurring Medea selfish genetic elements in the United States. ECOLOGY AND EVOLUTION, 9(24), 14407–14416. https://doi.org/10.1002/ece3.5876