{"id":2803,"date":"2026-10-28T13:43:05","date_gmt":"2026-10-28T13:43:05","guid":{"rendered":"https:\/\/research.ncsu.edu\/metric\/?page_id=2803"},"modified":"2026-10-28T15:50:26","modified_gmt":"2026-10-28T15:50:26","slug":"mass-spectrometry","status":"publish","type":"page","link":"https:\/\/research.ncsu.edu\/metric\/mass-spectrometry\/","title":{"rendered":"Mass Spectrometry"},"content":{"rendered":"\n\n\n\n
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Core Services
(Fee-for-Service)<\/h2>\n

This option is for researchers who wish to submit samples for analysis by Core staff. Results are returned as a data report, typically within 1 – 2 weeks depending on facility demand.<\/em><\/p>\n \n\n\n <\/div>\n\n\n

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\"Thermo<\/figure>\n\n<\/div>\n\n <\/div>\n <\/div>\n\n\n\n

Proteomics & Protein Characterization<\/strong><\/h3>\n\n\n\n
    \n
  • Targeted Protein Identification:<\/strong> Available for samples in-solution or via in-gel digestion.<\/li>\n\n\n\n
  • Intact Protein Mass Analysis:<\/strong> Verification of recombinant proteins, synthetic peptides, and antibodies. Ideal for confirming molecular weight, assessing purity, and identifying large-scale modifications.<\/li>\n\n\n\n
  • Interactome Analysis (Pull-downs):<\/strong> Identification of binding partners from AP\/MS (Affinity Purification) or Co-IP assays to elucidate protein-protein networks.<\/li>\n\n\n\n
  • Comparative Quantitative Proteomics:<\/strong> By digesting proteins into peptides and measuring their relative signal intensities through LC-MS\/MS, researchers can quantify and compare the abundance of thousands of proteins across two samples to identify significant biological shifts.<\/li>\n<\/ul>\n\n\n
    \n \n
    \n \n Learn more<\/span>\n\t\t\t\n\t\t\t\n\t\t<\/svg><\/span>\n <\/a>\n <\/div>\n \n\n <\/div>\n\n\n\n

    Targeted Metabolomics & Environmental Panels<\/strong><\/h3>\n\n\n\n
      \n
    • Amino Acid Panel:<\/strong> Measurement of relative abundance across standard amino acids.<\/li>\n\n\n\n
    • Central Carbon Metabolism Panel:<\/strong> Analysis of TCA cycle, glycolysis, and Pentose Phosphate Pathway (PPP) intermediates (relative abundance).<\/li>\n\n\n\n
    • Environmental Contaminants Panel:<\/strong> Analysis of select pesticides, herbicides, and other pollutants.<\/li>\n\n\n\n
    • Methyl Salicylate and Related Metabolites Panel: <\/strong>Analysis of methyl salicylate, salicylic acid, salicyluric acid, gentisic acid, salicylic acyl glucuronide, and salicylic phenolic glucuronide in human biological samples (urine and plasma).<\/li>\n\n\n\n
    • Targeted Ultrashort-chain and Legacy PFAS Panel: <\/strong>High-sensitivity detection of legacy per- and polyfluoroalkyl substances in biological and environmental matrices. Method has been recently updated to also include ultrashort-chain PFAS.<\/li>\n<\/ul>\n\n\n\n
      Details coming soon!<\/h5>\n\n\n
      \n
      \n \n
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      Self-Use Instrumentation<\/h2>\n

      The Core provides access to high-end instrumentation for trained independent users. All users must complete a mandatory training session before gaining scheduling privileges.<\/em><\/p>\n \n

      \n \n
      \n \n Learn more<\/span>\n\t\t\t\n\t\t\t\n\t\t<\/svg><\/span>\n <\/a>\n <\/div>\n \n\n <\/div>\n\n\n <\/div>\n\n\n
      \n\n
      \"Thermo<\/figure>\n\n<\/div>\n\n <\/div>\n <\/div>\n\n\n\n

      Available Instruments<\/strong><\/h3>\n\n\n\n
        \n
      • HRAM (High-Resolution Accurate Mass):<\/strong> For complex mixture analysis and molecular formula confirmation.<\/li>\n\n\n\n
      • GC-MS (Gas Chromatography-Mass Spectrometry):<\/strong> Ideal for volatile and semi-volatile compounds.<\/li>\n\n\n\n
      • MALDI-TOF (Matrix-Assisted Laser Desorption\/Ionization):<\/strong> Rapid analysis of polymers, proteins, and synthetic molecules.<\/li>\n\n\n\n
      • ICP-MS (Inductively Coupled Plasma Mass Spectrometry):<\/strong> High-sensitivity (ppt) elemental and metal analysis .<\/li>\n\n\n\n
      • QQQ (Triple Quadrupole):<\/strong> Optimized for high-sensitivity targeted absolute quantification using METRIC-validated workflows.<\/li>\n<\/ul>\n\n\n
        \n \n
        \n \n Learn more<\/span>\n\t\t\t\n\t\t\t\n\t\t<\/svg><\/span>\n <\/a>\n <\/div>\n \n\n <\/div>\n\n\n
        \n
        \n \n
        \n

        Collaborative Projects<\/h2>\n

        For complex studies requiring deep technical integration, experimental design support, and custom data interpretation. We encourage investigators to contact us during the grant-writing or experimental design phase.<\/em><\/p>\n \n

        \n \n
        \n \n Request a consultation<\/span>\n\t\t\t\n\t\t\t\n\t\t<\/svg><\/span>\n <\/a>\n <\/div>\n \n\n <\/div>\n\n\n <\/div>\n\n\n
        \n\n
        \"\"<\/figure>\n\n<\/div>\n\n <\/div>\n <\/div>\n\n\n\n

        We offer untargeted and targeted collaborative support in:<\/strong><\/h3>\n\n\n\n
          \n
        • Global Proteomics:<\/strong> Deep-dive protein expression profiling and PTM analysis.<\/li>\n\n\n\n
        • Global Metabolomics:<\/strong> Discovery-based profiling of cellular or biological fluids.<\/li>\n\n\n\n
        • Volatile Measurements:<\/strong> Analysis of the volatile organic compound (VOC) profile of biological systems.<\/li>\n\n\n\n
        • Custom Method Development:<\/strong> If our standard panels don’t fit your needs, we can collaborate to develop and validate novel LC-MS or GC-MS assays tailored to your specific analytes.<\/li>\n<\/ul>\n\n\n
          \n \n
          \n \n Request a consultation<\/span>\n\t\t\t\n\t\t\t\n\t\t<\/svg><\/span>\n <\/a>\n <\/div>\n \n\n <\/div>\n\n\n
          \n
          \n
          \n <\/svg>\n\n <\/div>\n
          \n

          Collaborative partnerships <\/h2>\n

          Projects outside our core services are collaborative. Best practices require that involved METRIC staff be credited as collaborators and listed as co-authors on resulting publications.<\/p>\n \n

          \n \n Citing METRIC<\/span>\n\t\t\t\n\t\t\t\n\t\t<\/svg><\/span>\n <\/a>\n <\/div>\n \n\n <\/div>\n <\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

          Proteomics & Protein Characterization Targeted Metabolomics & Environmental Panels Details coming soon! Available Instruments We offer untargeted and targeted collaborative support in:<\/p>\n","protected":false},"author":243,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"ncst_custom_author":"","ncst_show_custom_author":false,"ncst_dynamicHeaderBlockName":"ncst\/default-header","ncst_dynamicHeaderData":"{\"pageIntro\":\"Our goal is to provide expert analytical services to North Carolina State University researchers at a cost-effective rate using state-of-the-art instrumentation. \"}","ncst_content_audit_freq":"","ncst_content_audit_date":"","ncst_content_audit_display":false,"ncst_backToTopFlag":"","footnotes":""},"tags":[],"class_list":["post-2803","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nMass Spectrometry - METRIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/research.ncsu.edu\/metric\/mass-spectrometry\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mass Spectrometry - METRIC\" \/>\n<meta property=\"og:description\" content=\"Proteomics & Protein Characterization Targeted Metabolomics & Environmental Panels Details coming soon! 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