{"id":389,"date":"2020-12-14T14:36:48","date_gmt":"2020-12-14T14:36:48","guid":{"rendered":"https:\/\/dev.research.ncsu.edu\/metric-alt\/?page_id=389"},"modified":"2025-01-21T15:47:13","modified_gmt":"2025-01-21T15:47:13","slug":"metabolomics-and-lipidomics","status":"publish","type":"page","link":"https:\/\/research.ncsu.edu\/metric\/mass-spectrometry\/metabolomics-and-lipidomics\/","title":{"rendered":"Metabolomics"},"content":{"rendered":"\n\n\n\n\n
\"\"
An example of a data visualization output from a metabolomics study conducted by METRIC. This visualization shows a principal component analysis scores plot (A), variable importance in projections (VIP) plots (B and C), and hierarchical clustering heatmap (D) from MetaboAnalyst. Abbreviations: CF, control female; CM, control male; HF, high-dose female; HM, high-dose male.

From Kylie D Rock, Genevieve St Armour, Brian Horman, Allison Phillips, Matthew Ruis, Allison K Stewart, Dereje Jima, David C Muddiman, Heather M Stapleton, Heather B Patisaul, Effects of Prenatal Exposure to a Mixture of Organophosphate Flame Retardants on Placental Gene Expression and Serotonergic Innervation in the Fetal Rat Brain, Toxicological Sciences<\/em> 2020<\/strong> 176<\/em> (1), 203\u2013223. https:\/\/doi.org\/10.1093\/toxsci\/kfaa046<\/a><\/figcaption><\/figure>\n\n\n
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\n \n <\/div>\n <\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":273,"featured_media":0,"parent":117,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"ncst_custom_author":"","ncst_show_custom_author":false,"ncst_dynamicHeaderBlockName":"ncst\/default-header","ncst_dynamicHeaderData":"{\"pageIntro\":\"Metabolomics is the study of small molecule metabolites that are produced and consumed by chemical reactions throughout biological systems.\u00a0Mass spectrometry based metabolomics facilitates the measurement of ionizable components in a biological sample and subsequent identification of these metabolites using high resolution accurate mass measurements, isotopic distribution calculations for molecular formula determination and fragmentation matching using tandem mass spectrometry fingerprints.\u00a0Metabolomics studies provide a snapshot of the metabolite profile under various study conditions (e.g., control vs. diseased) and the results offer insight to the perturbation of biological pathways.\u00a0Front end separations typically involve liquid chromatography and routine methods for untargeted studies are often divided between polar (e.g., amino acids, sugars, organic acids) and non-polar metabolites (e.g., lipids). \"}","ncst_content_audit_freq":"","ncst_content_audit_date":"","ncst_content_audit_display":false,"ncst_backToTopFlag":"","footnotes":""},"tags":[],"class_list":["post-389","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nMetabolomics - 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