{"id":538,"date":"2021-05-11T19:20:54","date_gmt":"2021-05-11T19:20:54","guid":{"rendered":"https:\/\/dev.research.ncsu.edu\/metric-alt\/?page_id=538"},"modified":"2023-07-01T20:37:49","modified_gmt":"2023-07-01T20:37:49","slug":"biomolecular-structure-and-dynamics","status":"publish","type":"page","link":"https:\/\/research.ncsu.edu\/metric\/nmr-spectroscopy\/biomolecular-structure-and-dynamics\/","title":{"rendered":"Biomolecular Structure and Dynamics"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"614\" src=\"https:\/\/research.ncsu.edu\/metric-test\/files\/2022\/03\/Biomolecular.1dhpb-cn-700-hsqc-01-1024x614.png\" alt=\"\" class=\"wp-image-757\" srcset=\"https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Biomolecular.1dhpb-cn-700-hsqc-01-1024x614.png 1024w, https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Biomolecular.1dhpb-cn-700-hsqc-01-300x180.png 300w, https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Biomolecular.1dhpb-cn-700-hsqc-01-768x460.png 768w, https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Biomolecular.1dhpb-cn-700-hsqc-01-1536x921.png 1536w, https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Biomolecular.1dhpb-cn-700-hsqc-01-2048x1228.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption><sup>1<\/sup>H-<sup>15<\/sup>N HSQC of Dehaloperoxidase B from <em>Amphitrite ornata<\/em>, courtesy of Jessica Gonz\u00e1lez-Delgado, Franzen lab.<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1014\" height=\"1024\" src=\"https:\/\/research.ncsu.edu\/metric-test\/files\/2022\/03\/Biomolecular.2.dhp_mf-1014x1024.png\" alt=\"\" class=\"wp-image-758\" srcset=\"https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Biomolecular.2.dhp_mf-1014x1024.png 1014w, https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Biomolecular.2.dhp_mf-297x300.png 297w, https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Biomolecular.2.dhp_mf-150x150.png 150w, https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Biomolecular.2.dhp_mf-768x775.png 768w, https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Biomolecular.2.dhp_mf-1522x1536.png 1522w, https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Biomolecular.2.dhp_mf-2029x2048.png 2029w\" sizes=\"auto, (max-width: 1014px) 100vw, 1014px\" \/><figcaption>Model-free analysis of backbone dynamics contrasting Dehaloperoxidase A and Dehaloperoxidase B, courtesy of Jessica Gonz\u00e1lez-Delgado, Franzen lab.<\/figcaption><\/figure>\n\n\n<div class=\"wp-block-ncst-accordion ncst-accordion\"><div class=\"accordion\" id=\"ncst-accordion-0\"><div class=\"wp-block-ncst-accordion-item ncst-accordion-item panel\"><a class=\"accordion-item__header collapsed\" href=\"#ncst-accordion-item-0\" id=\"ncst-accordion-item-heading-0\" data-toggle=\"collapse\" data-target=\"#ncst-accordion-item-0\" rel=\"noopener noreferrer\"><span class=\"accordion-item__expansion-indicator\"><span class=\"ncst-plus-minus-toggle\"><\/span><\/span><h2 class=\"accordion-item__label h5\">Capabilities<\/h2><\/a><div class=\"collapse panel-collapse accordion-item__content-container \" id=\"ncst-accordion-item-0\" aria-labelledby=\"ncst-accordion-item-heading-0\" data-parent=\"#ncst-accordion-0\"><div class=\"accordion-item__content\">\n<ul class=\"wp-block-list\"><li>Experience in producing purified proteins and nucleic acids<\/li><li>High-sensitivity cryoprobes for soluble biomolecules<\/li><li>3D structure determination for proteins and nucleic acids<\/li><li><sup>19<\/sup>F analyses for site-specific labels<\/li><li>Shigemi-style tubes available for users<\/li><\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-ncst-accordion-item ncst-accordion-item panel\"><a class=\"accordion-item__header collapsed\" href=\"#ncst-accordion-item-1\" id=\"ncst-accordion-item-heading-1\" data-toggle=\"collapse\" data-target=\"#ncst-accordion-item-1\" rel=\"noopener noreferrer\"><span class=\"accordion-item__expansion-indicator\"><span class=\"ncst-plus-minus-toggle\"><\/span><\/span><h2 class=\"accordion-item__label h5\">Applications<\/h2><\/a><div class=\"collapse panel-collapse accordion-item__content-container \" id=\"ncst-accordion-item-1\" aria-labelledby=\"ncst-accordion-item-heading-1\" data-parent=\"#ncst-accordion-0\"><div class=\"accordion-item__content\">\n<ul class=\"wp-block-list\"><li>Small molecule binding screens<\/li><li>Uncovering and understanding allostery<\/li><li>Protein:protein interactions<\/li><li>Protein folding and stability<\/li><li>Riboswitch function<\/li><li>Aptamer characterization<\/li><\/ul>\n<\/div><\/div><\/div>\n\n<\/div><\/div>\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":953,"featured_media":0,"parent":119,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"ncst_custom_author":"","ncst_show_custom_author":false,"ncst_dynamicHeaderBlockName":"ncst\/default-header","ncst_dynamicHeaderData":"{\"pageIntro\":\"NMR spectroscopy is a valuable tool in the structural biologist\u2019s toolbox. It can be used to determine the 3-D structures of larger biomolecules, including proteins, nucleic acids, and polysaccharides. Knowledge of the structure aids in understanding how these biomolecules function and in how they interact with other molecules, large or small. We can also measure the motions these molecules undergo across multiple timescales. Linking these dynamics to the structure gives a fuller picture of how these molecules function and provides key insights into their interactions with other molecules. There are a myriad of NMR experiments and techniques available to researchers to answer these kinds of questions. Additionally, EPR can often provide valuable constraints in determining the structure of molecular complexes.\"}","ncst_content_audit_freq":"","ncst_content_audit_date":"","ncst_content_audit_display":false,"ncst_backToTopFlag":"","footnotes":""},"tags":[],"class_list":["post-538","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Biomolecular Structure and Dynamics - METRIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/research.ncsu.edu\/metric\/nmr-spectroscopy\/biomolecular-structure-and-dynamics\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biomolecular Structure and Dynamics - METRIC\" \/>\n<meta property=\"og:url\" content=\"https:\/\/research.ncsu.edu\/metric\/nmr-spectroscopy\/biomolecular-structure-and-dynamics\/\" \/>\n<meta property=\"og:site_name\" content=\"METRIC\" \/>\n<meta property=\"article:modified_time\" content=\"2023-07-01T20:37:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/research.ncsu.edu\/metric-test\/files\/2022\/03\/Biomolecular.1dhpb-cn-700-hsqc-01-1024x614.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/nmr-spectroscopy\\\/biomolecular-structure-and-dynamics\\\/\",\"url\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/nmr-spectroscopy\\\/biomolecular-structure-and-dynamics\\\/\",\"name\":\"Biomolecular Structure and Dynamics - METRIC\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/nmr-spectroscopy\\\/biomolecular-structure-and-dynamics\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/nmr-spectroscopy\\\/biomolecular-structure-and-dynamics\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/research.ncsu.edu\\\/metric-test\\\/files\\\/2022\\\/03\\\/Biomolecular.1dhpb-cn-700-hsqc-01-1024x614.png\",\"datePublished\":\"2021-05-11T19:20:54+00:00\",\"dateModified\":\"2023-07-01T20:37:49+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/nmr-spectroscopy\\\/biomolecular-structure-and-dynamics\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/nmr-spectroscopy\\\/biomolecular-structure-and-dynamics\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/nmr-spectroscopy\\\/biomolecular-structure-and-dynamics\\\/#primaryimage\",\"url\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/files\\\/2022\\\/03\\\/Biomolecular.1dhpb-cn-700-hsqc-01.png\",\"contentUrl\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/files\\\/2022\\\/03\\\/Biomolecular.1dhpb-cn-700-hsqc-01.png\",\"width\":6163,\"height\":3695},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/nmr-spectroscopy\\\/biomolecular-structure-and-dynamics\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Magnetic Resonance Spectroscopy\",\"item\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/nmr-spectroscopy\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Biomolecular Structure and Dynamics\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/#website\",\"url\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/\",\"name\":\"METRIC\",\"description\":\"Just another Research and Innovation site\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Biomolecular Structure and Dynamics - METRIC","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/research.ncsu.edu\/metric\/nmr-spectroscopy\/biomolecular-structure-and-dynamics\/","og_locale":"en_US","og_type":"article","og_title":"Biomolecular Structure and Dynamics - METRIC","og_url":"https:\/\/research.ncsu.edu\/metric\/nmr-spectroscopy\/biomolecular-structure-and-dynamics\/","og_site_name":"METRIC","article_modified_time":"2023-07-01T20:37:49+00:00","og_image":[{"url":"https:\/\/research.ncsu.edu\/metric-test\/files\/2022\/03\/Biomolecular.1dhpb-cn-700-hsqc-01-1024x614.png","type":"","width":"","height":""}],"twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/research.ncsu.edu\/metric\/nmr-spectroscopy\/biomolecular-structure-and-dynamics\/","url":"https:\/\/research.ncsu.edu\/metric\/nmr-spectroscopy\/biomolecular-structure-and-dynamics\/","name":"Biomolecular Structure and Dynamics - METRIC","isPartOf":{"@id":"https:\/\/research.ncsu.edu\/metric\/#website"},"primaryImageOfPage":{"@id":"https:\/\/research.ncsu.edu\/metric\/nmr-spectroscopy\/biomolecular-structure-and-dynamics\/#primaryimage"},"image":{"@id":"https:\/\/research.ncsu.edu\/metric\/nmr-spectroscopy\/biomolecular-structure-and-dynamics\/#primaryimage"},"thumbnailUrl":"https:\/\/research.ncsu.edu\/metric-test\/files\/2022\/03\/Biomolecular.1dhpb-cn-700-hsqc-01-1024x614.png","datePublished":"2021-05-11T19:20:54+00:00","dateModified":"2023-07-01T20:37:49+00:00","breadcrumb":{"@id":"https:\/\/research.ncsu.edu\/metric\/nmr-spectroscopy\/biomolecular-structure-and-dynamics\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/research.ncsu.edu\/metric\/nmr-spectroscopy\/biomolecular-structure-and-dynamics\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/research.ncsu.edu\/metric\/nmr-spectroscopy\/biomolecular-structure-and-dynamics\/#primaryimage","url":"https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Biomolecular.1dhpb-cn-700-hsqc-01.png","contentUrl":"https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Biomolecular.1dhpb-cn-700-hsqc-01.png","width":6163,"height":3695},{"@type":"BreadcrumbList","@id":"https:\/\/research.ncsu.edu\/metric\/nmr-spectroscopy\/biomolecular-structure-and-dynamics\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/research.ncsu.edu\/metric\/"},{"@type":"ListItem","position":2,"name":"Magnetic Resonance Spectroscopy","item":"https:\/\/research.ncsu.edu\/metric\/nmr-spectroscopy\/"},{"@type":"ListItem","position":3,"name":"Biomolecular Structure and Dynamics"}]},{"@type":"WebSite","@id":"https:\/\/research.ncsu.edu\/metric\/#website","url":"https:\/\/research.ncsu.edu\/metric\/","name":"METRIC","description":"Just another Research and Innovation site","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/research.ncsu.edu\/metric\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/pages\/538","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/users\/953"}],"replies":[{"embeddable":true,"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/comments?post=538"}],"version-history":[{"count":1,"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/pages\/538\/revisions"}],"predecessor-version":[{"id":1684,"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/pages\/538\/revisions\/1684"}],"up":[{"embeddable":true,"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/pages\/119"}],"wp:attachment":[{"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/media?parent=538"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/tags?post=538"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}