{"id":683,"date":"2022-03-02T15:40:02","date_gmt":"2022-03-02T15:40:02","guid":{"rendered":"https:\/\/dev.research.ncsu.edu\/metric-alt\/?page_id=683"},"modified":"2023-07-01T20:40:45","modified_gmt":"2023-07-01T20:40:45","slug":"targeted-small-molecule-assays","status":"publish","type":"page","link":"https:\/\/research.ncsu.edu\/metric\/mass-spectrometry\/targeted-small-molecule-assays\/","title":{"rendered":"Targeted Small Molecule Assays"},"content":{"rendered":"<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"310\" src=\"https:\/\/research.ncsu.edu\/metric-test\/files\/2022\/03\/Targeted-MS-1024x310.png\" alt=\"\" class=\"wp-image-1208\" srcset=\"https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Targeted-MS-1024x310.png 1024w, https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Targeted-MS-300x91.png 300w, https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Targeted-MS-768x233.png 768w, https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Targeted-MS-1536x466.png 1536w, https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Targeted-MS-2048x621.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption>An example depiction of the data analysis workflow for PFAS quantitation. MS1 and MS2 data (without dynamic exclusion) can be collected allowing for calibration in either the MS1 or MS2 dimension. Collection of MS2 data on high res equipment allows for dot product (dotp) qualitative verification.<br><br>From Enders, JR, Weed, RA, Griffith, EH, Muddiman, DC. Development and Validation of a High-Resolving Power Absolute Quantitative PFAS method Incorporating Skyline Data Processing. <em>Rapid Commun Mass Spectrom<\/em>. <strong>2022<\/strong>. Accepted Author Manuscript. e9295 <a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1002\/rcm.9295\" target=\"_blank\">https:\/\/doi.org\/10.1002\/rcm.9295<\/a><\/figcaption><\/figure><div class=\"wp-block-ncst-accordion ncst-accordion\"><div class=\"accordion\" id=\"ncst-accordion-0\"><div class=\"wp-block-ncst-accordion-item ncst-accordion-item panel\"><a class=\"accordion-item__header collapsed\" href=\"#ncst-accordion-item-0\" id=\"ncst-accordion-item-heading-0\" data-toggle=\"collapse\" data-target=\"#ncst-accordion-item-0\" aria-controls=\"ncst-accordion-item-0\" rel=\"noopener noreferrer\"><span class=\"accordion-item__expansion-indicator\"><span class=\"ncst-plus-minus-toggle\"><\/span><\/span><h2 class=\"accordion-item__label h5\">Sample Types<\/h2><\/a><div class=\"collapse panel-collapse accordion-item__content-container \" id=\"ncst-accordion-item-0\" aria-labelledby=\"ncst-accordion-item-heading-0\" data-parent=\"#ncst-accordion-0\"><div class=\"accordion-item__content\">\n<ul class=\"wp-block-list\"><li><strong>Biological Fluids and Tissues<\/strong>:<ul><li>Tissue: brain, liver, skin, testes, ovaries, embryos, placentas<\/li><li>Biofluids and biosolids: plasma, serum, CSF, urine, feces, cecal\/ileal content<\/li><\/ul><\/li><li><strong>Source Organisms:<\/strong><ul><li>Cell Culture (bacterial, fungal, human and murine cell-lines) &ndash; media or cell pellet<\/li><li>Plants (Arabidopsis, tomatoes) &ndash; roots, stem, leaves, etc<\/li><li>Model Organisms (zebrafish, mouse, rat)<\/li><\/ul><ul><li>Other: horse, canine, feline, insect<\/li><\/ul><\/li><li><strong>Environmental Matrices<\/strong>: Water, Ice-Cores, POCIS extracts, Soil, Landfill Leachate<br><\/li><\/ul>\n\n\n\n<p><em>Don&rsquo;t see your matrix of interest? Submit a <a href=\"https:\/\/go.ncsu.edu\/metricmsconsult\" target=\"_blank\" rel=\"noreferrer noopener\">MS Consultation<\/a> so we can discuss your project!<\/em><\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-ncst-accordion-item ncst-accordion-item panel\"><a class=\"accordion-item__header collapsed\" href=\"#ncst-accordion-item-1\" id=\"ncst-accordion-item-heading-1\" data-toggle=\"collapse\" data-target=\"#ncst-accordion-item-1\" aria-controls=\"ncst-accordion-item-1\" rel=\"noopener noreferrer\"><span class=\"accordion-item__expansion-indicator\"><span class=\"ncst-plus-minus-toggle\"><\/span><\/span><h2 class=\"accordion-item__label h5\">Targeted Assays<\/h2><\/a><div class=\"collapse panel-collapse accordion-item__content-container \" id=\"ncst-accordion-item-1\" aria-labelledby=\"ncst-accordion-item-heading-1\" data-parent=\"#ncst-accordion-0\"><div class=\"accordion-item__content\">\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/research.ncsu.edu\/metric\/files\/2022\/08\/PFAS-Brochure_Edits04.05.22-ElectronicVersion.pdf\">PFAS<\/a><\/li><li>Bile Acids<\/li><li>UDP-Sugars<\/li><li>Steroid Glucuronides<\/li><li>Eicosanoids<\/li><\/ul>\n<\/div><\/div><\/div>\n\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":953,"featured_media":0,"parent":117,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"ncst_custom_author":"","ncst_show_custom_author":false,"ncst_dynamicHeaderBlockName":"ncst\/default-header","ncst_dynamicHeaderData":"{\"pageIntro\":\"For some applications a targeted assay may be needed to provide quantitative information on compounds of interest. Development of these assays may be possible in some cases. Submit a <a href=\\\"https:\/\/go.ncsu.edu\/metricmsconsult\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">consultation request<\/a> to learn more.\"}","ncst_content_audit_freq":"","ncst_content_audit_date":"","ncst_content_audit_display":false,"ncst_backToTopFlag":"","footnotes":""},"tags":[],"class_list":["post-683","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Targeted Small Molecule Assays - METRIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/research.ncsu.edu\/metric\/mass-spectrometry\/targeted-small-molecule-assays\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Targeted Small Molecule Assays - METRIC\" \/>\n<meta property=\"og:url\" content=\"https:\/\/research.ncsu.edu\/metric\/mass-spectrometry\/targeted-small-molecule-assays\/\" \/>\n<meta property=\"og:site_name\" content=\"METRIC\" \/>\n<meta property=\"article:modified_time\" content=\"2023-07-01T20:40:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/research.ncsu.edu\/metric-test\/files\/2022\/03\/Targeted-MS-1024x310.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/mass-spectrometry\\\/targeted-small-molecule-assays\\\/\",\"url\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/mass-spectrometry\\\/targeted-small-molecule-assays\\\/\",\"name\":\"Targeted Small Molecule Assays - 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