{"id":1049,"date":"2022-03-15T23:40:53","date_gmt":"2022-03-15T23:40:53","guid":{"rendered":"https:\/\/dev.research.ncsu.edu\/metric-alt\/?p=1049"},"modified":"2022-10-03T19:18:47","modified_gmt":"2022-10-03T19:18:47","slug":"congratulations-to-arion-kennedy-awarded-nih-r21-grant","status":"publish","type":"post","link":"https:\/\/research.ncsu.edu\/metric\/2022\/03\/15\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\/","title":{"rendered":"Congratulations to Arion Kennedy, Awarded NIH R21 Grant"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Congratulations to Arion Kennedy, who just received her notice of award for a new NIH R21 grant entitled \u201cFructose Induced Regulation of Profibrogenic Factors in Hepatic Nonparenchymal Cells&#8221;. High fructose corn syrup consumption is strongly correlated with diabetes, obesity and nonalcoholic fatty liver disease (NAFLD). Fructose consumption is two to three times higher in patients with NAFLD compared to controls and increases the presence of lobular inflammation and fibrosis. The major contributors of lobular inflammation and fibrosis are activated hepatic nonparenchymal cells, which consist of T cells, stellate cells, and Kupffer cells. The distinct role of fructose metabolism on Kupffer cell phenotype and function in NAFLD is unclear. The goals of this project are to identify new molecular mechanisms by which fructose leads to the development of NAFLD, by uncovering metabolic pathways regulated by fructose that impact immune cell function. Preliminary data using NMR and MS to track and identify fructose metabolites in macrophages was obtained in METRIC with pilot project funding from the Kenan Institute.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Arion Kennedy&#8217;s research focuses on understanding the impacts of fructose metabolism on Kupffer cell phenotype and function in Non-Alcoholic Fatty Liver Disease (NAFLD).<\/p>\n","protected":false},"author":244,"featured_media":1506,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"ncst_custom_author":"","ncst_show_custom_author":false,"ncst_dynamicHeaderBlockName":"ncst\/default-post-header","ncst_dynamicHeaderData":"{\"showAuthor\":true,\"showDate\":true,\"showFeaturedVideo\":false,\"caption\":\"\",\"subtitle\":\"Arion Kennedy's research focuses on understanding the impacts of fructose metabolism on Kupffer cell phenotype and function in Non-Alcoholic Fatty Liver Disease (NAFLD).<br>\",\"displayCategoryID\":9}","ncst_content_audit_freq":"","ncst_content_audit_date":"","ncst_content_audit_display":false,"ncst_backToTopFlag":"","footnotes":""},"categories":[9],"tags":[],"_ncst_magazine_issue":[],"class_list":["post-1049","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general"],"displayCategory":{"term_id":9,"name":"General","slug":"general","term_group":0,"term_taxonomy_id":9,"taxonomy":"category","description":"","parent":0,"count":4,"filter":"raw"},"acf":{"ncst_posts_meta_modified_date":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Congratulations to Arion Kennedy, Awarded NIH R21 Grant - METRIC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/research.ncsu.edu\/metric\/2022\/03\/15\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Congratulations to Arion Kennedy, Awarded NIH R21 Grant - METRIC\" \/>\n<meta property=\"og:description\" content=\"Arion Kennedy&#039;s research focuses on understanding the impacts of fructose metabolism on Kupffer cell phenotype and function in Non-Alcoholic Fatty Liver Disease (NAFLD).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/research.ncsu.edu\/metric\/2022\/03\/15\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\/\" \/>\n<meta property=\"og:site_name\" content=\"METRIC\" \/>\n<meta property=\"article:published_time\" content=\"2022-03-15T23:40:53+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-03T19:18:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Arion_Kennedy.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"500\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"akstewar\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"akstewar\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/2022\\\/03\\\/15\\\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/2022\\\/03\\\/15\\\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\\\/\"},\"author\":{\"name\":\"akstewar\",\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/#\\\/schema\\\/person\\\/a0fe1b80a966f0cad2d292e63b44d6ef\"},\"headline\":\"Congratulations to Arion Kennedy, Awarded NIH R21 Grant\",\"datePublished\":\"2022-03-15T23:40:53+00:00\",\"dateModified\":\"2022-10-03T19:18:47+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/2022\\\/03\\\/15\\\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\\\/\"},\"wordCount\":174,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/2022\\\/03\\\/15\\\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/files\\\/2022\\\/03\\\/Arion_Kennedy.jpg\",\"articleSection\":[\"General\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/2022\\\/03\\\/15\\\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/2022\\\/03\\\/15\\\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\\\/\",\"url\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/2022\\\/03\\\/15\\\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\\\/\",\"name\":\"Congratulations to Arion Kennedy, Awarded NIH R21 Grant - METRIC\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/2022\\\/03\\\/15\\\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/2022\\\/03\\\/15\\\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/files\\\/2022\\\/03\\\/Arion_Kennedy.jpg\",\"datePublished\":\"2022-03-15T23:40:53+00:00\",\"dateModified\":\"2022-10-03T19:18:47+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/#\\\/schema\\\/person\\\/a0fe1b80a966f0cad2d292e63b44d6ef\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/2022\\\/03\\\/15\\\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/2022\\\/03\\\/15\\\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/2022\\\/03\\\/15\\\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\\\/#primaryimage\",\"url\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/files\\\/2022\\\/03\\\/Arion_Kennedy.jpg\",\"contentUrl\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/files\\\/2022\\\/03\\\/Arion_Kennedy.jpg\",\"width\":500,\"height\":500},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/2022\\\/03\\\/15\\\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Congratulations to Arion Kennedy, Awarded NIH R21 Grant\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/#website\",\"url\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/\",\"name\":\"METRIC\",\"description\":\"Bring your research to the next level \",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/#\\\/schema\\\/person\\\/a0fe1b80a966f0cad2d292e63b44d6ef\",\"name\":\"akstewar\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/4fa1c2b449b1d008f1379318c4be30073aac5d2b45d549d8bad5a4564ca2dbd2?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/4fa1c2b449b1d008f1379318c4be30073aac5d2b45d549d8bad5a4564ca2dbd2?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/4fa1c2b449b1d008f1379318c4be30073aac5d2b45d549d8bad5a4564ca2dbd2?s=96&d=mm&r=g\",\"caption\":\"akstewar\"},\"url\":\"https:\\\/\\\/research.ncsu.edu\\\/metric\\\/author\\\/akstewar\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Congratulations to Arion Kennedy, Awarded NIH R21 Grant - METRIC","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/research.ncsu.edu\/metric\/2022\/03\/15\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\/","og_locale":"en_US","og_type":"article","og_title":"Congratulations to Arion Kennedy, Awarded NIH R21 Grant - METRIC","og_description":"Arion Kennedy's research focuses on understanding the impacts of fructose metabolism on Kupffer cell phenotype and function in Non-Alcoholic Fatty Liver Disease (NAFLD).","og_url":"https:\/\/research.ncsu.edu\/metric\/2022\/03\/15\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\/","og_site_name":"METRIC","article_published_time":"2022-03-15T23:40:53+00:00","article_modified_time":"2022-10-03T19:18:47+00:00","og_image":[{"width":500,"height":500,"url":"https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Arion_Kennedy.jpg","type":"image\/jpeg"}],"author":"akstewar","twitter_card":"summary_large_image","twitter_misc":{"Written by":"akstewar","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/research.ncsu.edu\/metric\/2022\/03\/15\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\/#article","isPartOf":{"@id":"https:\/\/research.ncsu.edu\/metric\/2022\/03\/15\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\/"},"author":{"name":"akstewar","@id":"https:\/\/research.ncsu.edu\/metric\/#\/schema\/person\/a0fe1b80a966f0cad2d292e63b44d6ef"},"headline":"Congratulations to Arion Kennedy, Awarded NIH R21 Grant","datePublished":"2022-03-15T23:40:53+00:00","dateModified":"2022-10-03T19:18:47+00:00","mainEntityOfPage":{"@id":"https:\/\/research.ncsu.edu\/metric\/2022\/03\/15\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\/"},"wordCount":174,"commentCount":0,"image":{"@id":"https:\/\/research.ncsu.edu\/metric\/2022\/03\/15\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\/#primaryimage"},"thumbnailUrl":"https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Arion_Kennedy.jpg","articleSection":["General"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/research.ncsu.edu\/metric\/2022\/03\/15\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/research.ncsu.edu\/metric\/2022\/03\/15\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\/","url":"https:\/\/research.ncsu.edu\/metric\/2022\/03\/15\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\/","name":"Congratulations to Arion Kennedy, Awarded NIH R21 Grant - METRIC","isPartOf":{"@id":"https:\/\/research.ncsu.edu\/metric\/#website"},"primaryImageOfPage":{"@id":"https:\/\/research.ncsu.edu\/metric\/2022\/03\/15\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\/#primaryimage"},"image":{"@id":"https:\/\/research.ncsu.edu\/metric\/2022\/03\/15\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\/#primaryimage"},"thumbnailUrl":"https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Arion_Kennedy.jpg","datePublished":"2022-03-15T23:40:53+00:00","dateModified":"2022-10-03T19:18:47+00:00","author":{"@id":"https:\/\/research.ncsu.edu\/metric\/#\/schema\/person\/a0fe1b80a966f0cad2d292e63b44d6ef"},"breadcrumb":{"@id":"https:\/\/research.ncsu.edu\/metric\/2022\/03\/15\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/research.ncsu.edu\/metric\/2022\/03\/15\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/research.ncsu.edu\/metric\/2022\/03\/15\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\/#primaryimage","url":"https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Arion_Kennedy.jpg","contentUrl":"https:\/\/research.ncsu.edu\/metric\/files\/2022\/03\/Arion_Kennedy.jpg","width":500,"height":500},{"@type":"BreadcrumbList","@id":"https:\/\/research.ncsu.edu\/metric\/2022\/03\/15\/congratulations-to-arion-kennedy-awarded-nih-r21-grant\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/research.ncsu.edu\/metric\/"},{"@type":"ListItem","position":2,"name":"Congratulations to Arion Kennedy, Awarded NIH R21 Grant"}]},{"@type":"WebSite","@id":"https:\/\/research.ncsu.edu\/metric\/#website","url":"https:\/\/research.ncsu.edu\/metric\/","name":"METRIC","description":"Bring your research to the next level ","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/research.ncsu.edu\/metric\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/research.ncsu.edu\/metric\/#\/schema\/person\/a0fe1b80a966f0cad2d292e63b44d6ef","name":"akstewar","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/4fa1c2b449b1d008f1379318c4be30073aac5d2b45d549d8bad5a4564ca2dbd2?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/4fa1c2b449b1d008f1379318c4be30073aac5d2b45d549d8bad5a4564ca2dbd2?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/4fa1c2b449b1d008f1379318c4be30073aac5d2b45d549d8bad5a4564ca2dbd2?s=96&d=mm&r=g","caption":"akstewar"},"url":"https:\/\/research.ncsu.edu\/metric\/author\/akstewar\/"}]}},"_links":{"self":[{"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/posts\/1049","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/users\/244"}],"replies":[{"embeddable":true,"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/comments?post=1049"}],"version-history":[{"count":1,"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/posts\/1049\/revisions"}],"predecessor-version":[{"id":1334,"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/posts\/1049\/revisions\/1334"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/media\/1506"}],"wp:attachment":[{"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/media?parent=1049"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/categories?post=1049"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/tags?post=1049"},{"taxonomy":"_ncst_magazine_issue","embeddable":true,"href":"https:\/\/research.ncsu.edu\/metric\/wp-json\/wp\/v2\/_ncst_magazine_issue?post=1049"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}