Any research with human subjects at NC State must go through the NC State IRB. Unauthorized use of external IRBs is not permitted.

IRB Official Forms

Example Forms & Templates

Guidance for Application Preparation & Matters of Compliance

Research Associated With The Department of Defense (DoD)

Are you performing research with human subjects that is funded by the Department of Defense (DoD) and/or uses any DoD resources or people (including ROTC)? If so, your research is considered supported by DoD and you are subject to additional requirements from the DoD regarding human subjects research (including Exempt, Expedited, and Full Board Approvals).

DoD entities include (but may not be limited to) these groups: 

  • Air Force
  • Air Force Academy
  • Army
  • Coast Guard
  • Coast Guard Academy
  • Defense Advanced Research Projects Agency (DARPA)
  • Defense Intelligence Agency
  • LAS
  • Marines
  • Military Academy (West Point)
  • Missile Defense Agency
  • National Geospatial-Intelligence Agency
  • National Guard
  • National Security Agency
  • National War College
  • Naval Academy
  • Navy
  • Office of Naval Research
  • Pentagon Force Protection Agency
  • ROTC
  • Tricare Health System
  • U.S. Army Corps of Engineers
  • U.S. Naval Observatory

Additional Requirements for DoD supported research are noted in the guidance below. These requirements include specific content to be included in study documents and procedures, an additional review process with a Human Research Protection Officer (HRPO) outside of the NCSU IRB office, and possibly a Scientific Merit review. Please read through the guidance below in order to meet all of your additional requirements.

DoD Supported Research Requirements

If your research is approved by the IRB under Expedited procedures or via the Full Board, your study will need to undergo a Scientific Merit Review. Scientific Merit review is an independent review and approval that assesses the scientific merit of a study. Please find information regarding the Scientific Merit Review below.

The NCSU IRB office has created a form that can be completed for Scientific Merit reviews. Not all HRPO officers will accept this and they may have their own process, but you can try and use it.

Research Associated with the Biomedical Engineering Department

UNC-Chapel Hill and NC State have a joint Biomedical Engineering Department that is supported by both universities. All human subjects research that is biomedical in nature and completed by faculty, staff, and students affiliated with this joint department will submit their IRB applications to UNC-Chapel Hill’s IRB.

Please see this Guidance for more detailed information.

Biomedical Engineering Joint UNC – NCSU Agreement Information

Human Embryonic Stem Cell Research Guidance

The use of human stem cells in research provokes much debate in the United States. This debate centers around the ethical, legal and regulatory aspects and is primarily directed towards the use of Human Embryonic Stem Cells in research (hESC). The regulatory framework governing hESC research is promulgated by Presidential Executive Order, managed by the National Institute’s of Health and relies heavily on existing regulations governing research involving human subjects, substance management and biocontainment. NC State University will facilitate oversight of hESC research by staying abreast of the changing regulatory environment, assess best practices, network with local and regional subject matter experts, and advise the NC State leadership on needed support and actions associated with this important and promising research frontier.

A collection of resources designed to provide a better understanding of issues surrounding Human Embryonic Stem Cell use in research endeavors are available below.