{"id":839,"date":"2020-06-16T10:38:32","date_gmt":"2020-06-16T14:38:32","guid":{"rendered":"https:\/\/research.ncsu.edu\/win\/?p=839"},"modified":"2020-06-16T10:38:32","modified_gmt":"2020-06-16T14:38:32","slug":"advanced-animal-diagnostics-pivots-to-humans-for-covid-19-test-with-ncbiotech-boost","status":"publish","type":"post","link":"https:\/\/research.ncsu.edu\/win\/advanced-animal-diagnostics-pivots-to-humans-for-covid-19-test-with-ncbiotech-boost\/","title":{"rendered":"Advanced Animal Diagnostics pivots to humans for COVID-19 test, with NCBiotech boost<\/a>"},"content":{"rendered":"

RESEARCH TRIANGLE PARK<\/strong>\u00a0\u2014\u00a0Advanced Animal Diagnostics, as the name suggests, makes tests for animals, not humans.<\/p>\n

However, in the age of coronavirus, this small\u00a0ag tech company\u00a0from Morrisville finds itself \u201crepurposing\u201d its QScout blood test platform \u2014 designed to detect disease in\u00a0cattle \u2014 to now be used for screening COVID-19 in humans.<\/p>\n

\u201cWe always knew there were applications for technology in the human market,\u201d said AAD\u2019s CEO and President Joy Parr Drach. \u201cWe had planned to eventually develop products; we just hadn\u2019t expected to do that so soon.\u201d<\/p>\n

This month, it got a boost from the North Carolina Biotechnology Center when it picked the startup for the Wells Fargo Innovation Incubator, or IN2.<\/p>\n

Launched in 2017 with $5 million from the Wells Fargo Foundation, the Channel Partner Awards is a competitive program open to IN2 channel partners \u2014 a network of more than 60 cleantech and sustainability-focused incubators, accelerators, and universities that refer promising startups to the program<\/p>\n

\n

Qscout from Advanced Animal Diagnostics<\/p>\n<\/div>\n

As a channel partner, NCBiotech tapped AAD for this year\u2019s incubator, which accelerated its 2020 awards to provide $900,0000 in immediate relief to cleantech and sustainable agriculture startups managing through the economic disruption caused by COVID-19.<\/p>\n

AAD received $50,000, along with 17 other startups around the country.<\/p>\n

\u201cThis is certainly an opportunity that nobody would have expected to come out of the animal health diagnostic space,\u201d said Paul Ulanch, Ph.D., executive director for the Crop Commercialization Program at NCBiotech.<\/p>\n

\u201cThis is a chance to really help others. It\u2019s also an opportunity to move an ag tech company along. Now they\u2019re able to get the ball rolling.\u201d<\/p>\n

\u201cIf COVID-19 has done anything, it\u2019s taught us we live in a \u2018One Health\u2019 world,\u201d added AAD\u2019s founder and chief scientific officer\u00a0Rudy Rodriguez, who started the company in 2001. \u201cWe know our livestock technology can make a difference by precisely targeting antibiotic use, and we hope to make a difference with the world\u2019s fastest, most rugged white blood cell differential.\u201d<\/p>\n

QSCOUT TESTING SYSTEM<\/h4>\n

Parr Drach said the funds will allow the company to continue its efforts to file a 510(k) application for its human test with the U.S. Food and Drug Administration.<\/p>\n

A 510(k) is a premarket submission made to FDA to demonstrate that the device to be marketed is safe and effective.<\/p>\n

For years now, farmers have used AAD\u2019s QScout MLD test on dairies to detect subclinical mastitis or its QScout BLD blood test animal-side in feedlots to get a snapshot of a calf\u2019s immune system. The test runs on AAD\u2019s portable \u201clab-in-a-box\u201d diagnostic platform, the QScout Lab, which provides test results in 32 seconds to guide antibiotic use.<\/p>\n

This March, the race to pivot to a human test started when Parr Drach and Jasper Pollard, AAD\u2019s head of R&D, were meeting with a clinical care head at a hospital who tipped them off to the usefulness of a white blood cell differential in COVID-19.<\/p>\n

In that moment, Parr Drach realized that AAD\u2019s QScout test had the potential to be used on humans in the fight against COVID-19.<\/p>\n

\u201cOur test can save lives and extend our limited medical resources. If we can make that kind of contribution, how could we not pivot?\u201d she said.<\/p>\n

CASH AND BLOOD<\/h4>\n

For the last few months, Parr Drach and her small team have been collecting verification data to submit as part of its 510(k) application.\u00a0That includes conducting a study using donated human blood.<\/p>\n

NCBiotech, as it turns out, also helped in this regard.<\/p>\n

\u201cOur connection to the Biotech Center has been so helpful in so many ways,\u201d she said. \u201cStaff members have even bled for us.\u201d<\/p>\n

She wasn\u2019t kidding.<\/p>\n

Back in May, AAD set up an outdoor testing lab in its parking lot. It was one of series of collections where the team conducted the two-minute test\u00a0outside, alongside the patients using QScout technology. It was then sent to a central lab for comparison testing.<\/p>\n

Many NCBiotech staff members turned up to give blood, including Michelle VonCannon, NCBiotech\u2019s agriculture program and event manager.<\/p>\n

\u201cThey had their little tents and QScout machine. They drove up and had the phlebotomist there,\u201d she said.<\/p>\n

She didn\u2019t hesitate, even with her young son in tow: \u201cIt\u2019s vital to get faster diagnostics in order to get a better hold on containment. If donating blood is the least I can do, I\u2019m on board.\u201d<\/p>\n

NCBiotech helped fund its research and development from its time as a young startup, with a $20,000 loan back in 2006.<\/p>\n

The support helped the company attract equity capital from North Carolina investors, including Burlington-based LabCorp and Intersouth Partners of Durham, and from investors outside North Carolina including Novartis Venture Funds, Cultivian Sandbox, Middleland Capital and the Kansas Bioscience Authority.<\/p>\n

Parr Drach said she\u2019s grateful to NCBiotech for its support over the years, and to the volunteers who gave samples. She\u2019s also looking ahead.<\/p>\n

\u201cWe were very pleased with the performance of our test run outdoors \u2014 in a minute and a half, patient-side, when compared to the central lab test. That data has been used as part of our verification testing for an FDA submission. Our focus right now is how quickly can we get it into the hands of those who need it.\u201d<\/p>\n

(c) North Carolina Biotechnology Center<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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