Area(s) of Expertise

Paul received his Ph. D. while working with Dr. Toshiko Ichiye and studying redox proteins using molecular dynamics simulations and semi-empirical QM methods. Following were a post-doctoral position at University of Washington, Texas A&M University, University of North Carolina and North Carolina State University. Paul was then employed by North Carolina State University Department of Molecular and Structural Biochemistry to manage and operate the macromolecular x-ray crystallography laboratory and access to the beamlines available at Southeast Regional Collaborative Access Team (SERCAT). He has been in that position since 2004 and has assisted researchers in collecting data for, modelling, and depositing about 180 crystal structures to the PDB and preparing about 75 publications.

Publications

• Characterization of an isobutylene epoxide hydrolase (IbcK) from the isobutylene-catabolizing bacterium Mycolicibacterium sp. ELW1 , Applied and Environmental Microbiology (2025)
• The Heme Oxygenase-Like Diiron Enzyme HrmI Reveals Altered Regulatory Mechanisms for Dioxygen Activation and Substrate N-Oxygenation , Journal of the American Chemical Society (2025)
• Assembly of a Heterobimetallic Fe/Mn Cofactor in the para-Aminobenzoate Synthase Chlamydia Protein Associating with Death Domains (CADD) Initiates Long-Range Radical Hole-Hopping , Biochemistry (2024)
• A Ferric-Superoxide Intermediate Initiates P450-Catalyzed Cyclic Dipeptide Dimerization , Journal of the American Chemical Society (2023)
• Preliminary results of neutron and X-ray diffraction data collection on a lytic polysaccharide monooxygenase under reduced and acidic conditions , Acta Crystallographica Section F Structural Biology Communications (2021)
• Remodeling hydrogen bond interactions results in relaxed specificity of Caspase-3 , Bioscience Reports (2021)
• Caspases from scleractinian coral show unique regulatory features , Journal of Biological Chemistry (2020)
• Development of a structure-analysis pipeline using multiple-solvent crystal structures of barrier-to-autointegration factor , Acta Crystallographica Section D Structural Biology (2020)
• DRoP: Automated detection of conserved solvent‐binding sites on proteins , Proteins Structure Function and Bioinformatics (2019)
• Modifications to a common phosphorylation network provide individualized control in caspases , Journal of Biological Chemistry (2018)

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