Biomolecular Structure and Dynamics

NMR spectroscopy is a valuable tool in the structural biologist’s toolbox. It can be used to determine the 3-D structures of larger biomolecules, including proteins, nucleic acids, and polysaccharides. Knowledge of the structure aids in understanding how these biomolecules function and in how they interact with other molecules, large or small. We can also measure the motions these molecules undergo across multiple timescales. Linking these dynamics to the structure gives a fuller picture of how these molecules function and provides key insights into their interactions with other molecules. There are a myriad of NMR experiments and techniques available to researchers to answer these kinds of questions. Additionally, EPR can often provide valuable constraints in determining the structure of molecular complexes.