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Office of Research and Innovation
Research Administration and Compliance

PI Requirements

According to REG 10.10.01 Animal Care and Use Procedures, Principal Investigators must be of faculty rank or EHRA staff with approval of the department chairperson. Principal Investigators (PIs) are responsible for animal use by their students and staff. The PI heading a research group or teaching a course must have an approved application on file for each project or course using NC State-owned animals under his/her supervision. Collaborators, technicians, and students must care for and use animals according to the protocols described in the approved applications. 

Overview

PIs leaving NC State are responsible for notifying the IACUC Office or Attending Veterinarian in advance of their departure date to make arrangements for any current IACUC protocols.

Important Considerations for New Investigators:

  • North Carolina State University policy requires an approved Application for Vertebrate Animal Use (AVAU) for all activities involving the use of animals (research, teaching, public service; intramurally or extramurally funded regardless of source or amount; and including animals being bred, conditioned, or held for future use). The AVAU must be submitted through RED and approved by the IACUC before the start of related research or teaching activities.
  • You must submit a modification to an IACUC protocol in RED  and secure IACUC approval BEFORE implementing any changes.
  • You must adhere to all  IACUC Standards, Policies and Procedures.
  • You should be aware of regulations and guidelines governing the use of animals in research.
  • You must ensure that all laboratory personnel comply with IACUC-required training and are qualified to perform procedures for which they are responsible.
  • You must report any unexpected outcomes, deviations, or adverse events to the IACUC.
  • You must maintain appropriate records for animals (including anesthesia/surgery records, satellite housing records, breeding colony and all animal numbers for annual reporting), controlled substances, and training.