IACUC: Procedures and Guidance

Procedures

IACUC Committee

This section list the standard operating procedures for conducting IACUC reviews and other functions as required by regulatory agencies

• Veterinary Verification and Consultation (VVC) Reviews
• Administrative Review Procedures
• Review Procedures for Significant Changes in an Approved Protocol
• Protocol and Amendment Review
• Procedure for Semiannual Facility Inspections
• Animal Welfare Concerns and Noncompliance Situations

Principal Investigator

This section lists the standard operating procedures and responsibilities of the PI for creating and submitting an Application for Vertebrate Animal Use (AVAU) as required to conduct activities with animals on behalf of NC State University. 

• RED System Training: Animal Care and Use Module
• Guideline for Blanket Protocols
• AVMA Euthanasia Guidelines
• Guidance on Activities Requiring IACUC Approval
• Classification of Animal Use by Pain and Distress Categories
• Needs for Prospective Clinical Studies Using Client Owned Animals
• Disposition of Research and Teaching Animals
• Tracking of Approval and Approved Animal Numbers
• Justification of Numbers of Animals Used for Research, Teaching, and Outreach Activities
• NC State Rodent Cage Density and Breeding Standard
• Social Housing Standard
• Dos and Don’ts for Veterinarian Clinician Researchers
• Guidelines for Departing Investigators
• PI Requirements

IACUC Guidance

This section provides guidance on proper conduct of procedures with animals. 

• Use of Restraint in Vertebrate Animal Studies
• Use of Non-pharmaceutical-grade Compounds in Live Vertebrate Animals
• Required Health/Medical Record Keeping for Research and Teaching Animals
• Intra- and Postoperative Monitoring and Required Record Keeping for Surgery and Anesthesia
• Guidelines for major survival surgery performed on animals used in research, teaching, or testing
• Guidelines on Drop Method for Inhalational Anesthesia/Euthanasia in Rodents
• NC State Summary of NIH guidelines for Tissue Collection for Genotyping Rodents
• Tumor burden and appropriate time for euthanasia in animals
• Procedures for Decapitation as a Means of Euthanasia for Mice and Rats